022 The suppressive effect of kaempferol on type 2 inflammation in atopic dermatitis in mouse model

Atopic dermatitis is a chronic relapsing inflammatory common skin disease. It has complex pathophysiology, that involves strong genetic predisposition, epidermal dysfunction, and type 2 inflammation. Kaempferol natural flavonoid widely found in tea, vegetables, fruits. wide range of beneficial pharmacological activities, including excellent anti-oxidation anti-inflammation. However, the therapeutic effect kaempferol on atopic was unclear. We aimed to elucidate inflammation its inhibitory mechanism assessed suppressive administration calcipotriol-induced dermatitis-like mouse model investigated, quantification TEWL were performed. Histopathological study showed expression TSLP, cornified envelope proteins such as filaggrin, loricrin involucrin, numbers infiltrating cells lymphocytes, macrophages, mast into area. The IL4 IL13 investigated by real-time PCR flow cytometry analysis using tissue. treatment significantly suppressed dermatitis, infiltration (p<0.05). improved decreased involucrin site partially mice treated with seemed might improve via suppression improvement barrier dysfunction. have potential be new for dermatitis.